Journal
FOOT AND ANKLE CLINICS
Volume 22, Issue 2, Pages 267-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.fcl.2017.01.001
Keywords
Total; Ankle; Replacement; Arthroplasty; Periprosthetic; Osteolysis; Mechanisms; Pathophysiology
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Aseptic loosening of implants remains the most common reason for revision surgery for hip, knee, or ankle prostheses. Although a great scientific effort has been made to explain the underlying mechanisms it remains poorly understood, complex, and multifactorial. Many factors, including age, body weight, activity lesions, implant design, fixation methods, material proprieties, immunologic responses, and biomechanical adaptations to total ankle replacement all contribute to the development of periprosthetic osteolysis.
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