Journal
ACS OMEGA
Volume 2, Issue 5, Pages 2178-2183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.7b00209
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Funding
- National Natural Science Foundation of China [21431001, 81402817]
- Special Research Found for the Doctoral Program of Higher Education [20134504110002]
- Ministry of Education Innovation Team Fund [IRT_16R15]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2016-A02]
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Selagintamarlin A (1), a novel selaginellin analogue featuring the unique motif of 1H-2-benzopyran, a new selaginpulvilin E (2), together with eight known analogues were isolated from Selaginella tamariscina. Their structures were elucidated by extensive spectroscopic analyses. A plausible biosynthetic pathway of 1 was also postulated. Compound 1 showed remarkable inhibitory activity against phosphodiesterase-4 (PDE4D2), with an IC50 value of 40 nM, which is 20-fold higher than that of the positive control (rolipram). Furthermore, compound 1 significantly inhibited tubulin polymerization.
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