Journal
FOOD & FUNCTION
Volume 8, Issue 5, Pages 1905-1914Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7fo00227k
Keywords
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Funding
- Open Research Fund Program of Xinjiang Key Laboratory [2015KL001]
- Open Collaboration Program of MOE/MOH Key Laboratory of Medical Molecular Virology [FDMV-2017005]
- Chinese National Natural Science Foundation [31460241]
- Graduate Science and Technology Innovation Project of Xinjiang University [XJUBSCX-2014017]
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Pleurotus ferulae is an edible mushroom and has been used in Uygur medicine for a long time. In this study, we purified polysaccharides from P. ferulae (PFPS) and investigated its structural characteristics. We obtained a homogeneous PFPS with a molecular weight of around 1600 kDa and prominent characteristic polysaccharide groups, which mainly contained glucose (97%), followed by mannose and galactose (3%). Both H-1 and C-13 NMR spectra indicated that PFPS contained both alpha- and beta-anomeric configurations. Atomic force microscopy and Congo red-staining data further suggested that PFPS belonged to a linear branched structure that existed in flexible single chains at low concentrations and could form aggregates such as a triple-helical structure at high concentrations. Moreover, PFPS promoted the maturation of dendritic cells through a TLR4 mediated signaling pathway, which is characterized by the increased expressions of CD40, CD86, IL-12 and TNF-alpha and the decreased endocytosis. The results suggest that PFPS has immunoregulatory activities.
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