Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 31, Pages 8942-8973Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201612462
Keywords
biocatalysis; catalysis; enantioselectivity; retrosynthesis
Categories
Funding
- Royal Society
- Swiss National Science Foundation
- European Research Council [320666-CHLIP]
- ETH-Zurich
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Recent developments of stereoselective biocatalytic and chemo-catalytic methods are discussed. The review provides a guide to the use of biocatalytic methods in the area of chemical synthesis with focused attention on retrosynthetic considerations and analysis. The transformations presented are organized according to bond disconnections and attendant synthetic methods. The review is expected to lead to better understanding of the characteristics and distinctions of the two complementary approaches. It depicts for researchers in bio- and chemocatalysis a road map of challenges and opportunities for the evolution (and at times revolution) in chemical synthesis.
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