4.3 Article

Total Synthesis of Sphingofungin E and 4,5-Di-epi-sphingofungin E

Journal

CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 65, Issue 7, Pages 687-696

Publisher

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c17-00322

Keywords

sphingofungin E; dihydroxylation; stereoselectivity; osmium tetroxide; total synthesis

Funding

  1. Japan Society for the Promotion of Science (JSPS) [JP16K08158]
  2. JSPS Core-to-Core Program, B. Asia-Africa Science Platforms
  3. Grants-in-Aid for Scientific Research [16K08158] Funding Source: KAKEN

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Total synthesis of sphingofungin E and 4,5-di-epi-sphingofungin E was achieved from an intermediate same as that of myriocin and mycestericin D via antipodal stereoselective dihydroxylations.

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