Journal
ARCHIVES OF MICROBIOLOGY
Volume 199, Issue 6, Pages 881-890Publisher
SPRINGER
DOI: 10.1007/s00203-017-1362-5
Keywords
Cystic fibrosis; Aspergillus; Pseudomonas; Intermicrobial inhibition; Anaerobiasis; Hypoxia
Categories
Funding
- Child Health Research Institute, Stanford Transdisciplinary Initiatives Program, CIMR [3777]
Ask authors/readers for more resources
Pseudomonas aeruginosa (Pa) and Aspergillus fumigatus (Af) are the major bacterial and fungal pathogens in the airways of cystic fibrosis (CF) patients. This is likely related to their ability to form biofilms. Both microbes have been associated with CF disease progression. The interplay between these two pathogens has been studied under aerobic conditions, though accumulating data indicates that much of the CF airway is hypoxic or anaerobic. We studied the microbial interaction in these latter environments. Pa is an aggressor against Af forming biofilm or as established Af biofilm, whether Pa is cultivated in aerobic, hypoxic, or anaerobic conditions, or tested in aerobic or hypoxic conditions. Pa cells are generally more effective than planktonic or biofilm culture filtrates. Pa growth is less in anaerobic conditions, and filtrates less effective after anaerobic or hypoxic growth, or against hypoxic Af. These, and other comparisons shown, indicate that Pa would be less effective in such environments, as would be the case in a CF mucus plug. These observations would explain why Pa becomes established in CF airways before Af, and why Af may persist during disease progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available