Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 29, Pages 24440-24445Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b07307
Keywords
metal-organic framework; peroxidase-like activity; chromogenic reaction; pathogenic bacteria; Staphylococcus aureus
Funding
- National Natural Science Foundation of China [21305041]
- Program for Excellent Talents in Hunan Normal University [ET1503]
- Key Project of Research and Development Plan of Hunan Province [2016SK2020]
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Cu-MOF nanoparticles with an average diameter of 550 nm were synthesized from 2-aminoterephthalic acid and Cu(NO3)(2) by a mixed solvothermal method. The Cu-MOF nanoparticles can show peroxidase-like activity that can catalyze 3,3',5,5'-tetramethylbenzidine to produce a yellow chromogenic reaction in the presence of H2O2. The presence of abundant amine groups on the surfaces of Cu-MOF nanoparticles enables facile modification of Staphylococcus aureus (S. aureus) aptamer on Cu-MOF nanoparticles. By combining Cu-MOF-catalyzed chromogenic reaction with aptamer recognition and magnetic separation, a simple, sensitive, and selective colorimetric method for the detection of S. aureus was developed.
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