Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 42, Pages 10043-10047Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201702608
Keywords
amides; cobalt; cross-coupling; esterification; homogeneous catalysis
Categories
Funding
- Ministere de l'Enseignement Superieur et de la Recherche
- CNRS
- Ecole Polytechnique
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The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol%.
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