Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 32, Pages 9541-9545Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705105
Keywords
asymmetric catalysis; C-H activation; hydroalkenylation; hydroarylation; iridium
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Funding
- spanish MINECO [SAF2016-76689-R, CTQ2016-77047-P]
- Xunta de Galicia [GRC2013-041, 2015-CP082]
- Xunta de Galicia (Centro Singular de Investigacion de Galicia accreditation) [ED431G/09]
- European Union (European Regional Development Fund-ERDF)
- ERC [340055]
- MINECO
- European Research Council (ERC) [340055] Funding Source: European Research Council (ERC)
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A catalytic, versatile and atom-economical C-H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a cationic Ir-I-bisphosphine catalyst, which promotes a carboxamide-assisted activation of an olefinic C(sp(2))-H bond followed by exo-cyclization to a tethered 1,1-disubstituted alkene. The extension of the method to aromatic and heteroaromatic C-H bonds, as well as developments on an enantioselective variant, are also described.
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