Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 43, Pages 10280-10284Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201702593
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB 749, B2, C6]
- German Academic Scholarship Foundation
Ask authors/readers for more resources
An ambient temperature continuous flow method for nucleophilic amidation and thioamidation is described. Deprotonation of formamides by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophiles such as ketones, allyl bromides, Weinreb and morpholino amides. The nature of the reactive lithium intermediates and the thermodynamics of the metalation were further investigated by ab initio calculations and kinetic experiments.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available