Journal
BIOMATERIALS
Volume 136, Issue -, Pages 98-114Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.05.013
Keywords
Magnetic nanoparticles; Stimuli-responsive; Ligand; Controlled release; Cancer imaging; Cancer therapy
Funding
- Research Center Program of the Institute for Basic Science (IBS) in Korea [IBS-R006-D1]
- National Key Research and Development Program of China [2016YFA0203600]
- National Natural Science Foundation of China [51503180, 5161101036]
- Thousand Talents Program for Distinguished Young Scholars [588020*G81501/048]
- Fundamental Research Funds for the Central Universities [520002*172210161]
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Magnetic nanoparticles (MNPs) have been extensively studied for their potential applications to cancer diagnosis and treatment. However, various obstacles limit the use of nanoparticles for delivery in the tumor microenvironment. As a viable solution to such obstacles, advances in nanoparticle surface engineering augmented by a profound understanding of cancer physiology present new opportunities for MNP-based imaging and therapeutic agents. Stimuli-responsive ligands, rationally designed to interact with various physicochemical aspects, can improve the performance of MNPs in cancer-targeted imaging and therapy. In this review, we highlight recent progress in the design of MNP-based stimuli-responsive nanomaterials and their applications to cancer diagnosis and treatment. (C) 2017 Elsevier Ltd. All rights reserved.
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