Journal
TRENDS IN CANCER
Volume 3, Issue 8, Pages 571-582Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2017.06.002
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Funding
- Dutch Cancer Foundation [KWF UU 2013-5801]
- Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/75747/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/75747/2011] Funding Source: FCT
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The epithelial-to-mesenchymal transition (EMT) is an important developmental program exploited by cancer cells to gain mesenchymal features. Transcription factors globally regulating processes during EMT are often referred as 'master regulators' of EMT, and include members of the Snail and ZEB transcription factor families. The SRY-related HMG box (SOX) 4 transcription factor can promote tumorigenesis by endowing cells with migratory and invasive properties, stemness, and resistance to apoptosis, thereby regulating key aspects of the EMT program. We propose here that SOX4 should also be considered as a master regulator of EMT, and we review the molecular mechanisms underlying its function.
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