Unprecedented C19-diterpenoid alkaloid glycosides from an aqueous extract of fu zi: Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls

Four structurally unprecedented aconitane-type C-19-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A-D (1-4), were isolated from an aqueous extract of fu zi, the lateral roots of Aconitum carmichaelii. Their structures were determined as neoline 14-0-alpha- and 14-0-beta-L-arabinopyranosides (1 and 2) and 14-0-a- and 14-0-beta-L-arabinofuranosides (3 and 4), by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1-4 represent the first examples of glycosidic diterpenoid alkaloids. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.