Journal
FEMS MICROBIOLOGY LETTERS
Volume 364, Issue 15, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnx128
Keywords
interspecific interactions: multispecies interactions; microbiome; cystic fibrosis; Pseudomonas aeruginosa; microbial communities
Categories
Funding
- Wellcome Trust through the Centre for Chronic Diseases and Disorders (C2D2) at the University of York [105 624]
- ETH Zurich
- Leverhulme Trust
- Medical Research Foundation
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Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients. However, it is now recognised that a diverse microbial community exists in the airways comprising aerobic and anaerobic bacteria as well as fungi and viruses. This rich soup of microorganisms provides ample opportunity for interspecies interactions, particularly when considering secreted compounds. Here, we discuss how P. aeruginosa-secreted products can have community-wide effects, with the potential to ultimately shape microbial community dynamics within the lung. We focus on three well-studied traits associated with worsening clinical outcome in CF: phenazines, siderophores and biofilm formation, and discuss how secretions can shape interactions between P. aeruginosa and other commonly encountered members of the lung microbiome: Staphylococcus aureus, the Burkholderia cepacia complex, Candida albicans and Aspergillus fumigatus. These interactions may shape the evolutionary trajectory of P. aeruginosa while providing new opportunities for therapeutic exploitation of the CF lung microbiome.
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