Journal
THERAPEUTIC DELIVERY
Volume 8, Issue 9, Pages 753-761Publisher
FUTURE SCI LTD
DOI: 10.4155/tde-2017-0059
Keywords
bacterial nanocellulose; controlled release; drug delivery; production; storage
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Funding
- Free State of Thuringia
- European Social Fund [2016 FGR 0045]
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Although bacterial nanocellulose (BNC), a natural nanostructured biopolymer network, offers unique material characteristics, the number of drug-loaded BNC-based carriers in clinical trials or on the market is still low. This report provides an overview of aspects still limiting the broad application of BNC as drug-delivery system and the challenges for its future applications. Continuous large-scale production, storability, the loading and controlled release of critical drugs, for example, with high molar mass or highly lipophilic character as well as the formulation of long-term release systems will be highlighted. Recent achievements toward promoting the application of BNC as drug-delivery system and overcoming these obstacles will be discussed. [GRAPHICS] .
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