Journal
CARBOHYDRATE POLYMERS
Volume 169, Issue -, Pages 357-365Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.04.030
Keywords
Bacterial nanocellulose; Controlled release; Diclofenac sodium salt; Drug delivery; pH-responsiveness; Poly(N-methacryloyl glycine)
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Funding
- project CICECO-Aveiro Institute of Materials (FCT) [POCI-01-0145-FEDER-007679, UID/CTM/50011/2013]
- FCT/MEC - FEDER
- Erasmus + Erasmus Mundus Programme of the European Union
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BPD/84168/2012, SFRH/BPD/111736/2015, IF/01407/2012]
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The present study reports the development of non-cytotoxic and pH-sensitive nanostructured membranes consisting of a polymer with amino acid pending moieties and bacterial nanocellulose (BC). The nanocomposites were prepared through a simple methodology under green reaction conditions. The obtained materials display good thermal stability (up to 200 degrees C), viscoelastic (storage modulus > 700 MPa) and mechanical (Young's modulus =3.5-4.9 GPa) properties, together with high water uptake capacity. The results of the in vitro MTT assay showed that the nanocomposites are non-cytotoxic to HaCaT cells for 72 h. The in vitro release profile of diclofenac sodium salt (DCF) from the nanocomposites into simulated body fluids at different pH values demonstrates the pH-responsive behaviour of these materials. Besides, DCF is mainly retained in the nanocomposites at pH 2.1 and released at pH 7.4, revealing their potential for the controlled release of DCF in dermal as well as in oral drug delivery applications. (C) 2017 Elsevier Ltd. All rights reserved.
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