Journal
CELL METABOLISM
Volume 26, Issue 2, Pages 292-300Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2017.07.008
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Funding
- German Research Foundation (DFG) [KFO 114, STE 1096/1-3]
- German Federal Ministry of Education and Research (BMBF)
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A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (similar to 20% of the normal weight adult population) have a greater than 3-fold higher risk of all-cause mortality and/or cardiovascular events. Here we address to what extent major risk phenotypes determine metabolic health in lean compared to overweight and obese people and provide support for the existence of a lipodystrophy-like phenotype in the general population. Furthermore, we highlight the molecular mechanisms that induce this phenotype. Finally, we propose strategies as to how this knowledge could be implemented in the prevention and treatment of cardiometabolic diseases in different stages of adiposity in routine clinical practice.
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