Journal
CARBOHYDRATE POLYMERS
Volume 169, Issue -, Pages 441-450Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.04.027
Keywords
Chitosan derivatives; Staphylococcus aureus; Bacillus cereus; Escherichia coli; Pseudomonas aeruginosa
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Funding
- [VEGA2/0065/15]
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Cinnamaldehyde was immobilized to O-amine functionalized chitosan via a coupling reaction. Fourier transform infrared spectroscopy confirmed N-cinnamyl substitution. Wetting analyses demonstrate more hydrophobicity in the N-cinnamyl substituted O-amine functionalized chitosan compared to chitosan or unsubstituted O-amine functionalized chitosan. Thermal gravimetric analysis and differential scanning calorimetry demonstrates that the prepared N-cinnamyl substituted O-amine functionalized chitosan exhibits higher thermostability than unmodified chitosan at temperatures in which polysaccharides are commonly stored and utilised. The N-cinnamyl substituted O-amine functionalized chitosan, against four different bacteria strains [two gram-positive (Staphylococcus aureus and Bacillus cereus) and two gram -negative (Escherichia coli and Pseudomonas aeruginosa)], displays promotion of inhibition activity against these bacterial strains. Finally, the antioxidative activity of the N-cinnamyl substituted O-amine functionalized chitosan was compared with those activities of chitosan and O-amine functionalized chitosan. This was evaluated by uninhibited and inhibited hyaluronan degradation and ABTS assay. The N-cinnamyl substituted O-amine functionalized chitosan shows a lower activity towards donating a hydrogen radical compared to chitosan or O-amine functionalized chitosan. On the other hand, the Ncinnamyl substituted O-amine functionalized chitosan exhibited a higher ability to scavenge the ABTS' cation radical compared to chitosan and O-amine functionalized chitosan. (C) 2017 Elsevier Ltd. All rights reserved.
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