Journal
BIOMEDICAL OPTICS EXPRESS
Volume 8, Issue 11, Pages 4855-4864Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.8.004855
Keywords
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Funding
- GIST Research Institute (GRI)
- GIST-Caltech Research Collaboration [NRF-2016R1A2B4015381]
- Brain Research Program of the National Research Foundation (NRF) [NRF-2017M3C7A 1044964]
- KBRI basic research program through Korea Brain Research Institute - Ministry of Science, ICT, Future Planning [17-BR-04]
- industrial convergence foundation construction program - Ministry of Trade, Industry & Energy, and the National Institutes of Health (NIH) [N0002310, U01NS090577]
- National Institute of Biomedical Imaging, and Bioengineering under a Ruth L. Kirschstein National Research Service Award [F31EB021153]
- Donna and Benjamin M. Rosen Bioengineering Center
- Korea Evaluation Institute of Industrial Technology (KEIT) [10063364] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Ministry of Science & ICT (MSIT), Republic of Korea [17-BR-04] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2017M3C7A1044964] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The strong optical scattering of biological tissue confounds our ability to focus light deeply into the brain beyond depths of a few hundred microns. This challenge can be potentially overcome by exploiting wavefront shaping techniques which allow light to be focused through or inside scattering media. However, these techniques require the scattering medium to be static, as changes in the arrangement of the scatterers between the wavefront recording and playback steps reduce the fidelity of the focus that is formed. Furthermore, as the thickness of the scattering medium increases, the influence of the dynamic nature becomes more severe due to the growing number of scattering events experienced by each photon. In this paper, by examining the scattering dynamics in the mouse brain in vivo via multispeckle diffusing wave spectroscopy (MSDWS) using a custom fiber probe that simulates a point-like source within the brain, we investigate the relationship between this decorrelation time and the depth of the point-like light source inside the living mouse brain at depths up to 3.2 mm. (C) 2017 Optical Society of America
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