Journal
BIOMEDICAL OPTICS EXPRESS
Volume 8, Issue 7, Pages 3163-3197Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.8.003163
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Funding
- Helmholtz Association port-folio theme (Supercomputing and Modeling for the Human Brain)
- European Union's Horizon 2020 Research and Innovation Programme (Human Brain Project SGA1) [7202070]
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3D-polarized light imaging (3D-PLI) reconstructs nerve fibers in histological brain sections by measuring their birefringence. This study investigates another effect caused by the optical anisotropy of brain tissue -diattenuation. Based on numerical and experimental studies and a complete analytical description of the optical system, the diattenuation was determined to be below 4% in rat brain tissue. It was demonstrated that the diattenuation effect has negligible impact on the fiber orientations derived by 3D-PLI. The diattenuation signal, however, was found to highlight different anatomical structures that cannot be distinguished with current imaging techniques, which makes Diattenuation Imaging a promising extension to 3D-PLI. (C) 2017 Optical Society of America
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