Journal
BIOMATERIALS
Volume 135, Issue -, Pages 85-95Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.05.005
Keywords
3D printing; Bioceramic scaffold; Hollow pipe; Vascularization; Bone regeneration
Funding
- National Key Research and Development Program of China [2016YFC1102900, 2016YFB0700803]
- National Natural Science Foundation of China [81430012, 81271114]
- Shanghai Sailing Program [17YF1410800]
- Young Elite Scientist Sponsorship Program by CAST
- Science and Technology Commission of Shanghai Municipality [15XD1502500]
- Leading Talent of Taishan Industry
- Materials Genome Program of Shanghai [16DZ2260603]
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Segmental bone regeneration remains a considerable challenge due to the associated low degree of vascularization. To solve this problem, in this study, hollow-pipe-packed silicate bioceramic (BRT-H) scaffolds are fabricated using a coaxial three-dimensional (3D) printing technique. Based on a modified core/shell printer nozzle and a modulated viscoelastic bioceramic paste, hollow struts with an external diameter of 1 mm and internal dimeter of 500 mm can be directly printed, yielding a compressive strength of the BRT-H scaffolds as high as 26 MPa. Apart from the effects on osteogenesis, the bioactive ions released from the BRT scaffolds can also facilitate angiogenesis via inducing endothelial cell migration. More importantly, the hollow pipes not only significantly promote the rapid infiltration of host blood vessels into the channels but also exhibit great advantages for the delivery of stem cells and growth factors to further enhance tissue regeneration. When used for the regeneration of rabbit radius segmental defects, radiological and histological findings indicate that the BRT-H scaffolds can enhance early vascularization and later bone regeneration and remodeling. Taken together, the hollow pipes and the ionic products from BRT-H scaffolds have a synergistic effect on enhancing vascularized bone regeneration. (C) 2017 Published by Elsevier Ltd.
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