Journal
BIOMEDICAL OPTICS EXPRESS
Volume 8, Issue 2, Pages 873-889Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.8.000873
Keywords
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Funding
- National Sciences and Engineering Research Council (NSERC) [RGPIN-355623-08]
- Canadian Institutes of Health Research (CIHR) [CPG-121050, MOP-119603]
- Connaught Fund [498042]
- MITACS [IT02018]
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We developed a multi-modal brain imaging system to investigate the relationship between blood flow, blood oxygenation/volume, intracellular calcium and electrographic activity during acute seizure-like events (SLEs), both before and after pharmacological intervention. Rising blood volume was highly specific to SLE-onset whereas blood flow was more correlated with all eletrographic activity. Intracellular calcium spiked between SLEs and at SLE-onset with oscillation during SLEs. Modified neurovascular and ionic SLE responses were observed after intervention and the interval between SLEs became shorter and more inconsistent. Comparison of artery and vein pulsatile flow suggest proximal interference and greater vascular leakage prior to intervention. (C) 2017 Optical Society of America
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