Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1863, Issue 8, Pages 2056-2063Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2016.11.008
Keywords
Alternative splicing; Sarcomeric genes; Splicing factor; Heart failure
Funding
- National Institute of General Medical Sciences [1003088F]
- American Heart Association (AHA) [1003018]
- Agricultural Experiment Station's competitive Grant from USDA/NIFA [1003093K]
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Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eulcaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed. (C) 2016 Elsevier B.V. All rights reserved.
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