Label-free monitoring of the thrombin-aptamer recognition reaction using an array of nanochannels coupled with electrochemical detection

A sensitive and label-free method of monitoring the thrombin-aptamer recognition reaction has been developed using an array of nanochannels coupled with an electrochemical detection technique. Due to the highly amplified ion current produced by an array of nanochannels compared to a single nanochannel/pore, a significant increase in detection sensitivity has been achieved.