Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 38, Issue -, Pages 51-58Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.04.003
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Funding
- NIH grant [GM39422, GM44844, F32GM121000]
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Self-splicing introns and inteins are often mobile at the level of the genome. Although these RNA and protein elements, respectively, are generally considered to be selfish parasites, group I and group II introns and inteins can be triggered by environmental cues to splice and/or to mobilize. These cues include stressors such as oxidizing agents, reactive oxygen and nitrogen species, starvation, temperature, osmolarity and DNA damage. Their sensitivity to these stimuli leads to a carefully choreographed dance between the mobile element and its host that is in tune with the cellular environment. This responsiveness to a changing milieu provides strong evidence that these diverse, self-splicing mobile elements have adapted to react to prevailing conditions, to the potential advantage of both the element and its host.
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