Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 13, Issue 1, Pages 998-1010Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2017.09.003
Keywords
Copper(I) complexes; Antitumor activity; Diimine ligands; Phosphine ligands; Water soluble
Categories
Funding
- University of Padova [60A04-0443, 60A04-3189, 60A04-4015/15]
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Copper(I) complexes including diimine ligands of the bicinchoninic acid (BCA) and bathocuproinedisulfonic acid (BCS) families and water-soluble phosphines have been synthetized, characterized and investigated for their in vitro anticancer potential against human tumor cell lines representing examples of lung, breast, pancreatic and colon cancers and melanoma. All copper complexes exhibited moderate to high cytotoxic activity and the ability to overcome cisplatin resistance. Remarkably, growth-inhibitory effects evaluated in human non-transformed cells revealed a preferential cytotoxicity versus neoplastic cells. The remarkable cytotoxic effect towards BxPC3 pancreatic cancer cells, notoriously poor sensitive to cisplatin, was not related to a DNA or proteasome damage. (C) 2017 The Authors. Published by Elsevier B.V. on behalf of King Saud University
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