Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 13, Issue 1, Pages 193-204Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2017.03.009
Keywords
Polysulfobetaine; Metal coordination; Antibacterial; Self-healing; Hydrogels; Catecholamine polymers
Categories
Funding
- Qatar University [QUUG-CAM-2017-1]
- Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]
- Maersk Oil R&TC Qatar project
- Qatar National Research Fund (Qatar Foundation) [9 - 219-2-105]
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In the present study, the sulfobetaine-based copolymer bearing a dopamine functionality showed gel formation adjusted by the application of metal salts for gelation and various values of pH. Normally, the liquid-like solution of the sulfobetaine-based copolymer and metal cross-linkers is transformed to a gel-like state upon increasing the pH values in the presence of Fe3+ and Ti3+. Metal-induced coordination is reversible by means of the application of EDTA as a chelating agent. In the case of Ag+ ions, the gel is formed through a redox process accompanied with the oxidative coupling of the dopamine moieties and Ag-0 particle formation. Mussel-mimicking and metal-dependent viscoelastic properties were observed for Fe3+, Ti3+, and Ag+ cross-linking agents, with additionally enhanced self-healing behavior in comparison with the covalently cross-linked IO4- analogues. Antibacterial properties can be achieved both in solution and on the surface using the proper concentration of Ag+ ions used for gelation; thus, a tunable amount of the Ag-0 particles are formed in the hydrogel. The cytotoxicity was elucidated by the both MTT assay on the NIH/3T3 fibroblast cell line and direct contact method using human dermal fibroblast cell (F121) and shows the non-toxic character of the synthesized copolymer. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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