Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 10, Issue 2, Pages 206-214Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2014.05.007
Keywords
Biginelli reaction; Ionic liquid; Triethylammonium acetate; Antioxidant activity; Reaction medium; Antibacterial activity
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Funding
- SRC program of National Research Foundation of Korea (NRF) Grant - Korean Government (MEST) [20100029418]
- Kwangwoon University
- DST, Govt. of India
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A mild and efficient catalytic method has been developed to synthesize 3,4-dihydropyrimidinones in high yield by one-pot three component Biginelli condensation in the presence of triethylammonium acetate (TEAA) which acts as catalyst/reaction medium. Further, we have studied the antioxidant and antibacterial activities of these synthesized 3,4-dihydropyrimidinones. All the synthesized compounds reveal the significant antioxidant properties, these properties have been studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and cupric reducing antioxidant capacity (CUPRAC) assays. In addition, to this, these compounds also show the good antibacterial activity against four human pathogenic bacteria. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.
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