Related references
Note: Only part of the references are listed.A phase 2 study of MK-5442, a calcium-sensing receptor antagonist, in postmenopausal women with osteoporosis after long-term use of oral bisphosphonates
F. Cosman et al.
OSTEOPOROSIS INTERNATIONAL (2016)
Preventing the Spread of Alzheimer's Disease Neuropathology: A Role for Calcilytics?
Anna Chiarini et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2015)
The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1)
Fadil M. Hannan et al.
ENDOCRINOLOGY (2015)
The calcium-sensing receptor: one of a kind
Irene Lopez-Fernandez et al.
EXPERIMENTAL PHYSIOLOGY (2015)
Polyclonality of Parathyroid Tumors in Neonatal Severe Hyperparathyroidism
Kristin R. Corrado et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2015)
Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH)
Bingzi Dong et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2015)
Cinacalcet Treatment in an Adolescent With Concurrent 22q11.2 Deletion Syndrome and Familial Hypocalciuric Hypercalcemia Type 3 Caused by AP2S1 Mutation
Sirpa Tenhola et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)
The calcium-sensing receptor in bone-mechanistic and therapeutic insights
David Goltzman et al.
NATURE REVIEWS ENDOCRINOLOGY (2015)
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma
Polina L. Yarova et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension
Aya Yamamura et al.
PLOS ONE (2015)
Activating calcium-sensing receptor gene variants in children: a case study of infant hypocalcaemia and literature review
Signe B. Thim et al.
ACTA PAEDIATRICA (2014)
AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women
Markus R. John et al.
BONE (2014)
Novel homozygous inactivating mutation of the calcium-sensing receptor gene (CASR) in neonatal severe hyperparathyroidism-lack of effect of cinacalcet
Zeynep Atay et al.
BONE (2014)
Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics
Ya-Xiong Tao et al.
ENDOCRINE REVIEWS (2014)
The PRIMARA study: a prospective, descriptive, observational study to review cinacalcet use in patients with primary hyperparathyroidism in clinical practice
P. Schwarz et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2014)
CaSR mutants disrupting the disulfide bond between C582 and C568 in the cysteine-rich domain of the CaSR do not act as dominant negative mutants
S. Letz et al.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2014)
Severe but not neonatally lethal. A homozygous inactivating CaSR mutation in a 3 year old child
D. Schnabel et al.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2014)
Neonatal Severe Hyperparathyroidism due to Compound Heterozygous Mutation of Calcium Sensing Receptor (CaSR) Gene Presenting as Encephalopathy
Abhishek Kulkarni et al.
INDIAN JOURNAL OF PEDIATRICS (2014)
A Homozygous CaSR Mutation Causing a FHH Phenotype Completely Masked by Vitamin D Deficiency Presenting as Rickets
Dorothea Szczawinska et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
Functional Activities of Mutant Calcium-Sensing Receptors Determine Clinical Presentations in Patients With Autosomal Dominant Hypocalcemia
Yuka Kinoshita et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
Autosomal Dominant Hypoparathyroidism Caused by Germline Mutation in GNA11: Phenotypic and Molecular Characterization
Dong Li et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
Codon Arg15 Mutations of the AP2S1 Gene: Common Occurrence in Familial Hypocalciuric Hypercalcemia Cases Negative for Calcium-Sensing Receptor (CASR) Mutations
Geoffrey N. Hendy et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
Cinacalcet Monotherapy in Neonatal Severe Hyperparathyroidism: A Case Study and Review
Anthony W. Gannon et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
A novel CASR mutation associated with neonatal severe hyperparathyroidism transmitted as an autosomal recessive disorder
Alicia Diaz-Thomas et al.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2014)
Amino Alcohol- (NPS-2143) and Quinazolinone-Derived Calcilytics (ATF936 and AXT914) Differentially Mitigate Excessive Signalling of Calcium-Sensing Receptor Mutants Causing Bartter Syndrome Type 5 and Autosomal Dominant Hypocalcemia
Saskia Letz et al.
PLOS ONE (2014)
Pharmacoperones and the calcium sensing receptor: Exogenous and endogenous regulators
Gerda E. Breitwieser
PHARMACOLOGICAL RESEARCH (2014)
A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria
Eugenio Mastromatteo et al.
BMC ENDOCRINE DISORDERS (2014)
Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders
Edward F. Nemeth et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women
Stephen Caltabiano et al.
BONE (2013)
Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914
So Young Park et al.
CLINICAL ENDOCRINOLOGY (2013)
RECOMBINANT HUMAN PARATHYROID HORMONE THERAPY (1-34) IN AN ADULT PATIENT WITH A GAIN-OF-FUNCTION MUTATION IN THE CALCIUM-SENSING RECEPTOR-A CASE REPORT
Michael C. Gonzales et al.
ENDOCRINE PRACTICE (2013)
Impact of Clinically Relevant Mutations on the Pharmacoregulation and Signaling Bias of the Calcium-Sensing Receptor by Positive and Negative Allosteric Modulators
Katie Leach et al.
ENDOCRINOLOGY (2013)
Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity
Anne-Sophie Lia-Baldini et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2013)
Extrapyramidal Symptoms and Advanced Calcification of the Basal Ganglia in a Patient with Autosomal Dominant Hypocalcemia
Akira Kurozumi et al.
INTERNAL MEDICINE (2013)
Cinacalcet as Adjunctive Therapy for Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets
Tarak Srivastava et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
Loss-of-Function and Gain-of-Function Mutations of Calcium-Sensing Receptor: Functional Analysis and the Effect of Allosteric Modulators NPS R-568 and NPS 2143
Akie Nakamura et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3
M. Andrew Nesbit et al.
NATURE GENETICS (2013)
Neonatal Hypercalcemia due to a Homozygous Mutation in the Calcium-Sensing Receptor: Failure of Cinacalcet
Eduardo Garcia Soblechero et al.
NEONATOLOGY (2013)
Germline Mutations Affecting Gα11 in Hypoparathyroidism
Michael Mannstadt et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia
M. Andrew Nesbit et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Cinacalcet in Patients with Chronic Kidney Disease: A Cumulative Meta-Analysis of Randomized Controlled Trials
Suetonia C. Palmer et al.
PLOS MEDICINE (2013)
New concepts in calcium-sensing receptor pharmacology and signalling
Donald T. Ward et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Pharmacokinetic and Pharmacodynamic Properties of the Calcimimetic Agent Cinacalcet (KRN1493) in Healthy Male Korean Subjects: A Randomized, Open-Label, Single Ascending-Dose, Parallel-Group Study
SeungHwan Lee et al.
CLINICAL THERAPEUTICS (2012)
Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites
Fadil M. Hannan et al.
HUMAN MOLECULAR GENETICS (2012)
Long-Term Follow-Up of Patients with Hypoparathyroidism
Deborah M. Mitchell et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
Minireview: The Intimate Link Between Calcium Sensing Receptor Trafficking and Signaling: Implications for Disorders of Calcium Homeostasis
Gerda E. Breitwieser
MOLECULAR ENDOCRINOLOGY (2012)
Successful Use of Bisphosphonate and Calcimimetic in Neonatal Severe Primary Hyperparathyroidism
Alexandra Wilhelm-Bals et al.
PEDIATRICS (2012)
A novel CaSR mutation presenting as a severe case of neonatal familial hypocalciuric hypercalcemia
Ksenia N. Tonyushkina et al.
INTERNATIONAL JOURNAL OF PEDIATRIC ENDOCRINOLOGY (2012)
Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey
Friedhelm Raue et al.
CLINICAL ENDOCRINOLOGY (2011)
Neonatal severe hyperparathyroidism: further clinical and molecular delineation
Fawziya A. Al-Khalaf et al.
EUROPEAN JOURNAL OF PEDIATRICS (2011)
Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis
Leo Widler
FUTURE MEDICINAL CHEMISTRY (2011)
Neonatal Hyperparathyroidism with a Heterozygous Calcium-Sensing Receptor (CASR) R185Q Mutation: Clinical Benefit from Cinacalcet
Christina M. S. Reh et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
The Effects of Ronacaleret, a Calcium-Sensing Receptor Antagonist, on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Women with Low Bone Mineral Density
Lorraine A. Fitzpatrick et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Autosomal Dominant Hypoparathyroidism with Severe Hypomagnesemia and Hypocalcemia, Successfully Treated with Recombinant PTH and Continuous Subcutaneous Magnesium Infusion
S. Sanda et al.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2011)
Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects
Hannsjoerg W. Seyberth et al.
PEDIATRIC NEPHROLOGY (2011)
Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude
Michael P. Grant et al.
SCIENCE SIGNALING (2011)
Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR)
Edward M. Brown
BIOCHEMICAL PHARMACOLOGY (2010)
Residue 826 in the Calcium-Sensing Receptor Is Implicated in the Response to Calcium and to R-568 Calcimimetic Compound
Daniel Alvarez-Hernandez et al.
CALCIFIED TISSUE INTERNATIONAL (2010)
Phenotypic Variation in a Large Family with Autosomal Dominant Hypocalcaemia
J. I. Sorheim et al.
HORMONE RESEARCH IN PAEDIATRICS (2010)
Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant Receptors
Saskia Letz et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)
Calcimimetic R-568 effects on activity of R990G polymorphism of calcium-sensing receptor
Annalisa Terranegra et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2010)
Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia
Uri S. Alon et al.
PEDIATRIC NEPHROLOGY (2010)
Physiology and pathophysiology of the calcium-sensing receptor in the kidney
Daniela Riccardi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)
Unusually severe phenotype of neonatal primary hyperparathyroidism due to a heterozygous inactivating mutation in the CASR gene
Barbora Obermannova et al.
EUROPEAN JOURNAL OF PEDIATRICS (2009)
PTH(1-34) Replacement Therapy in a Child With Hypoparathyroidism Caused by a Sporadic Calcium Receptor Mutation
Todd A. Theman et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2009)
A Novel Loss-of-Function Mutation, Gln459Arg, of the Calcium-Sensing Receptor Gene Associated with Apparent Autosomal Recessive Inheritance of Familial Hypocalciuric Hypercalcemia
Steven A. Lietman et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Effect of the Calcimimetic R-568 [3-(2-Chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on Correcting Inactivating Mutations in the Human Calcium-Sensing Receptor
Jenny Ying Lin Lu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Pharmacochaperone-Mediated Rescue of Calcium-Sensing Receptor Loss-of-Function Mutants
Elissa White et al.
MOLECULAR ENDOCRINOLOGY (2009)
Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations
Ogo I. Egbuna et al.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2008)
Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets
Uri S. Alon et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Novel Inactivating Mutations of the Calcium-Sensing Receptor: The Calcimimetic NPS R-568 Improves Signal Transduction of Mutant Receptors
Ramona Rus et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
Cinacalcet for secondary hyperparathyroidism in children with end-stage renal disease
Jutta Muscheites et al.
PEDIATRIC NEPHROLOGY (2008)
Neonatal hyperparathyroidism and pamidronate therapy in an extremely premature infant
Lisa Fox et al.
PEDIATRICS (2007)
Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene
Judit Toke et al.
CLINICAL ENDOCRINOLOGY (2007)
Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms:: Role of G protein-coupled receptor kinases, protein kinase C and β-arrestins
Stephan Lorenz et al.
ENDOCRINOLOGY (2007)
Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis
Ying Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Hypocalciuric hypercalcemia presenting as neonatal rib fractures - A newly described mutation of the calcium-sensing receptor gene
Kristin Nyweide et al.
PEDIATRIC EMERGENCY CARE (2006)
Normalization of serum calcium by cinacalcet in a patient with hypercalcaemia due to a de novo inactivating mutation of the calcium-sensing receptor
H. J. . L. M. Timmers et al.
JOURNAL OF INTERNAL MEDICINE (2006)
A hypocalcemic child with a novel activating mutation of the calcium-sensing receptor gene: Successful treatment with recombinant human parathyroid hormone
Steven D. Mittelman et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+
JX Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism
M Peacock et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain
C Petrel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Autosomal dominant hypocalcemia in monozygotic twins caused by a De Novo germline mutation near the amino-terminus of the human calcium receptor
JX Hu et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2004)
Calcimimetic and calcilytic drugs: just for parathyroid cells?
EF Nemeth
CELL CALCIUM (2004)
Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor
A Scillitani et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
The calcimimetic agent KRN 1493 lowers plasma parathyroid hormone and ionized calcium concentrations in patients with chronic renal failure on haemodialysis both on the day of haemodialysis and on the day without haemodialysis
N Ohashi et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Neonatal severe hyperparathyroidism: genotype/phenotype correlation and the use of pamidronate as rescue therapy
S Waller et al.
EUROPEAN JOURNAL OF PEDIATRICS (2004)
CASRdb: Calcium-sensing receptor locus-specific database for mutations causing familial (Benign) hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia
S Pidasheva et al.
HUMAN MUTATION (2004)
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca2+-sensing receptor
C Petrel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Extracellular calcium sensing and signalling
AM Hofer et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
A family of autosomal dominant hypocalcemia with an activating mutation of calcium-sensing receptor gene
N Chikatsu et al.
ENDOCRINE JOURNAL (2003)
Autosomal dominant hypocalcemia: A novel activating mutation (E604K) in the cysteine-rich domain of the calcium-sensing receptor
YM Tan et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites
ZX Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome
R Vargas-Poussou et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
Association between activating mutations of calcium-sensing receptor and Bartter's syndrome
S Watanabe et al.
LANCET (2002)
The search for calcium receptor antagonists (calcilytics)
EF Nemeth
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2002)
Hydrochlorothiazide effectively reduces urinary calcium excretion in two Japanese patients with gain-of-function mutations of the calcium-sensing receptor gene
K Sato et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
M Gowen et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
A large homozygous or heterozygous in-frame deletion within the calcium-sensing receptor's carboxylterminal cytoplasmic tail that causes autosomal dominant hypocalcemia
A Lienhardt et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2000)
Share Paper
