Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 10, Issue -, Pages S2890-S2895Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2013.11.018
Keywords
Chalcones; Anti-bacterial activity; Chloramphenicol
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Chalcone derivatives have been synthesized by the reaction of 3-acetyl-2,5-dimethylthiophene with corresponding active aldehyde in ethanolic NaOH in microwave oven. The structure of these compounds was established by elemental analysis, IR, H-1 NMR, C-13 NMR and EI-MS spectral analysis. The anti-bacterial activity of these compounds were first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug Chloramphenicol. The results showed that compound 8 is a better inhibitor of both types of the bacteria (Gram-positive and Gram-negative) as compared to chloramphenicol. (C) 2014 Production and hosting by Elsevier B.V.
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