Basketing nanopalladium into calix[4]pyrrole as an efficient catalyst for Mizoroki-Heck reaction

An approach to synthesize calix[4]pyrrole protected palladium nanoparticles (PdNPs) employed for catalytic Mizoroki-Heck C-C coupling reaction is reported. The nanoparticles are synthesized in water using novel calix[4]pyrrole tetrahydrazide (CPTH) as a reducing as well as stabilizing agent which is a proficient one-pot synthesis discouraging the need of an external stabilizer. CPTH-PdNPs have been characterized and studied by UV-Vis spectroscopy, Fourier transform infrared, transmission electron microscopy, energy-dispersive X-ray and powder X-ray diffraction. The synthesized palladium nanoparticles with a size range of 5-9 nm show an efficient catalytic activity for Heck cross-coupling reactions giving good yields within short reaction time in comparison with conventional palladium catalyst. Also, a good degree of recyclability is shown by the nanocatalyst with five consecutive catalytic cycles. CPTH-PdNPs also exhibit a potential antimicrobial activity against gram-negative bacteria which shows the biological applicability of the synthesized CPTH-PdNPs. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.