Solvent-free synthesis of α-aminophosphonates: Cellulose-SO3H as an efficient catalyst

alpha-Aminophosphonates possess a broad range of applications ranging from agrochemistry to medicine. We developed an efficient and eco-friendly Cellulose-SO3H catalyzed one-pot synthesis of alpha-aminophosphonates by three-component, room temperature reaction of an aldehyde, an amine and dialkylphosphite under solvent-free conditions. The major advantages of the present method are simple experimentation, use of inexpensive and eco-friendly reusable catalyst with good yields and short reaction times. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.