Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 10, Issue -, Pages S157-S173Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2012.07.017
Keywords
Benzimidazole; Pharmacological activity; Antimicrobial activity
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Synthesis of commercially available benzimidazole involves condensation of o-phenylenediamine with formic acid. The most prominent benzimidazole compound in nature is N-riosyldimethylbenzimidazole, which serves as a axial ligand for cobalt in vitamin B12. The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc. The substituted benzimidazoles are summarized in this review to know about the chemistry as well as pharmacological activities. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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