Journal
DRUG DISCOVERY TODAY
Volume 22, Issue 8, Pages 1134-1138Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2017.01.010
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- University of Ferrara [F72I15000470005]
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Poorly soluble and/or permeable molecules jeopardize the discovery and development of innovative medicines. Pharmaceutical co-crystals, formed by an active pharmaceutical substance (API) and a co-crystal former, can show enhanced dissolution and permeation values compared with those of the parent crystalline pure phases. It is currently assumed that co-crystallization with pharmaceutical excipients does not affect the pharmacological activity of an API or, indeed, might even improve physical properties such as solubility and permeability. However, as we highlight here, the biological behavior of co-crystals can differ drastically with respect to that of their parent physical mixtures.
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