Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 44, Pages 10496-10500Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201702767
Keywords
hyperpolarization; long-lived singlet states; NMR spectroscopy; para-hydrogen; structure elucidation
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Funding
- Wellcome Trust [092506, 098335]
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Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in C-13 nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190 s in low-field, which leads to a C-13-signal that is visible for 10 minutes.
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