Journal
CHROMATOGRAPHIA
Volume 80, Issue 8, Pages 1171-1177Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10337-017-3335-x
Keywords
HPLC; Amino acid amide derivatives; Enantioseparation; Thermodynamic analysis; Polysaccharide; Chiral stationary phases
Funding
- National Natural Science Foundation of China [21372034]
- Science and Technology Department of Sichuan Province [2016HH0074]
- Education Department of Sichuan Province [16ZA0084]
- Chengdu Science and Technology Bureau [2015-HM01-00362-SF]
- State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Independent Research Project [SKLGP2016Z004]
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Enantioseparation of ten kinds of amino acid amide derivatives bearing aniline moieties on three polysaccharide-based chiral stationary phases (CSPs) was first systematically investigated. The chromatographic experiments were performed in the normal phase mode, namely, with n-hexane and 2-propanol as mobile phase. The effects of chiral columns, concentration of 2-propanol and column temperature on the enantioseparation were studied in detail. These compounds can be well resolved on Chiralcel OD-H column with the resolution above 1.5. Enantioseparation mechanism of chiral analytes and the CSPs are proposed based on the thermodynamic analysis of the experimental data. Our study establishes a simple, fast and efficient analytical method for amino acid amide derivatives by chiral HPLC, and provides a reference for enantioseparation of chiral amino acid amide derivatives and similar chiral compounds.
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