Journal
CLINICAL IMMUNOLOGY
Volume 181, Issue -, Pages 83-88Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2017.06.006
Keywords
Glatiramer acetate; Multiple sclerosis; Treg; M2 monocytes
Categories
Funding
- TEVA Italia S.r.l [IMM-2013-5]
- Fondazione Ricerca Biomedica Onlus
- Fondazione Italiana Sclerosi Multipla [FISM 2014/PMS/1]
Ask authors/readers for more resources
Glatiramer acetate (GA) is a widely used treatment for multiple sclerosis (MS), with incompletely defined mechanism of action. Short-term studies suggested its involvement in the modulation of anti-inflammatory cytokines and regulatory T cells (Treg), while long-term effect is still unknown. To investigate this aspect, we analyzed by flow-cytometry peripheral-blood Treg, natural killer (NK), CD4 and CD8 T-cells and anti-inflammatory CD14(+)CD163(+) monocytes from 37 healthy donor and 90 RRMS patients divided in untreated, treated with GA for 12 months and from 34 to 192 months. While NK, CD4 and CD8 T-cells did not show any significant differences among groups over time, we demonstrated that GA increased the anti-inflammatory monocytes and restored the Treg level in both GA-treated groups. Both these effects are a characteristic of responder patients and are observed not just in short-term but even after as long as a decade of GA treatment. (C) 2017 Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available