Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 33, Pages 9847-9850Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705148
Keywords
droplet microfluidics; flow chemistry; high-throughput screening; microreactors; photocatalysis
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Funding
- Novartis Center for Continuous Manufacturing
- National Science Foundation [1122374]
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We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 mL scale. An oscillatory flow strategy enables a flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux made possible with the platform is characterized using actinometry. Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities and advantages of the system. Reaction conditions identified through droplet screening translate directly to continuous synthesis with minor platform modifications.
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