Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 33, Pages 9680-9703Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201610129
Keywords
bioorthogonality; biotransformations; enzyme catalysis; synthetic biology; unnatural amino acids
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Funding
- DFG [FOR1805]
- FP7 EU-funded METACODE [289572]
- FP7 EU-funded SYNPEPTIDE Consortia [613981]
- UniCat Excellence Cluster of the TU Berlin
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The goal of xenobiology is to design biological systems endowed with unusual biochemical functions, whereas enzymology concerns the study of enzymes, the workhorses of biocatalysis. Biocatalysis employs enzymes and organisms to perform useful biotransformations in synthetic chemistry and biotechnology. During the past few years, the effects of incorporating noncanonical amino acids (ncAAs) into enzymes with potential applications in biocatalysis have been increasingly investigated. In this Review, we provide an overview of the effects of new chemical functionalities that have been introduced into proteins to improve various facets of enzymatic catalysis. We also discuss future research avenues that will complement unnatural mutagenesis with standard protein engineering to produce novel and versatile biocatalysts with applications in synthetic organic chemistry and biotechnology.
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