4.7 Article

A divergent [5+2] cascade approach to bicyclo[3.2.1] octanes: facile synthesis of ent-kaurene and cedrene-type skeletons

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 60, Pages 8435-8438

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc04292b

Keywords

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Funding

  1. Zhejiang Natural Science Fund for Distinguished Young Scholars [LR16B020001]
  2. National Natural Science Foundation of China [21622205, 21472167]
  3. Fundamental Research Funds for the Central Universities [2017XZZX002-02]

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A solvent-dependent oxidative dearomatization-induced divergent [5+2] cascade approach to bicyclo[3.2.1] octanes was described. This novel protocol enables a facile synthesis of a series of diversely functionalized ent-kaurene and cedrene-type skeletons in good yields and excellent diastereoselectivities.

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