Journal
ACS CATALYSIS
Volume 7, Issue 12, Pages 8588-8593Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b03370
Keywords
CO2 transformation; asymmetric tandem reaction; carboxylative cyclization; A(3) coupling; 2-oxazolidinone
Categories
Funding
- 973 Program [2015CB856600]
- NSFC [21502053, 21573073, 21472049, 21725203]
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We report a tandem asymmetric aldehyde-alkyne-amine (A(3)) coupling-carboxylative cyclization sequence for the highly enantioselective synthesis of chiral N-aryl 2-oxazolidinones. This is a rare example of a multicatalyst-promoted asymmetric tandem reaction using CO2 as a Cl synthon. Notably, the copper species and ligand from the upstream A(3) reaction are internally reused to facilitate the downstream silver-catalyzed carboxylative cyclization.
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