Journal
ACS CATALYSIS
Volume 7, Issue 8, Pages 5316-5320Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b01855
Keywords
atropisomer; homogeneous catalysis; palladium; C-H cyclization; indole
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Funding
- 973 project from the MOST of China [2015CB856600]
- NSFC [21472179, 21622206]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
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We report here a palladium-catalyzed enantioselective synthesis of indole-based atropisomers via an intramolecular dynamic kinetic C-H cyclization. The TADDOL-derived phosphoramidite ligand proves to be most efficient in this directing-group-free transformation, delivering products with up to 96:4 er. The thermal stability of the axial chirality of the atropisomers has also been investigated.
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