Journal
ACS CATALYSIS
Volume 7, Issue 12, Pages 8171-8175Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b03056
Keywords
gamma-C-H activation; silylation; germanylation; organopalladium aystal; mechanistic studies; DFT
Categories
Funding
- SERB [EMR/2015/000164]
- CSIR-India
- UGC-India
- IITB
- SERB
- SpaceTime supercomputing facility
Ask authors/readers for more resources
A Pd(II)-catalyzed protocol for highly regioselective distal gamma-C-H silylation and germanylation of aliphatic carboxylic acids is reported. Bidentate 8-aminoquinoline as the directing group was found to stabilize the six-membered palladacycle. A variety of aliphatic carboxylic acids and amino acids were silylated and germanylated in good yields and high diasteroselectivities. Detailed mechanistic studies involving isolation of a Pd(II) intermediate, determination of the reaction rate and order, control experiments, and isotopic labeling and DFT studies were found to be crucial for elucidating the elementary steps involved in this distal aliphatic functionalization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available