Journal
ACS CATALYSIS
Volume 7, Issue 12, Pages 8263-8284Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b02686
Keywords
transaminases; biocatalysis; amines; biocatalyst engineering; metagenomics; enzyme immobilization
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Funding
- BBSRC
- BIOINTENSE project through the European Union seventh Framework Programme [312148]
- ERC
- [BB/K013076/1]
- Biotechnology and Biological Sciences Research Council [1488840] Funding Source: researchfish
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Transaminases have attracted considerable interest in their use as biocatalysts for the synthesis of compounds containing chiral amine units, which are widespread within the pharmaceutical, agrochemical, and fine chemical industry. Recent developments in enzyme-and process-engineering have expedited their use in asymmetric synthesis; however, industrial applications are still hindered by a number of factors, including equilibrium thermodynamics, product inhibition, and poor substrate tolerance. Detailed and comprehensive approaches to each of these challenges have been reported during the last two decades; the most representative enzyme discovery and screening strategies, protein and equilibrium engineering, and immobilization techniques are reviewed herein. Furthermore, we present a detailed look into the applications of transaminases for the synthesis of a variety of amine containing compounds and the integration of transaminases into multienzymatic systems that allow access to a variety of highly complex products for the end user.
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