Journal
ANNALI DELL ISTITUTO SUPERIORE DI SANITA
Volume 53, Issue 2, Pages 125-134Publisher
PENSIERO SCIENTIFICO EDITORE
DOI: 10.4415/ANN_17_02_08
Keywords
chronic pelvic pain; dysmenorrhea, dyspareunia; endometriosis; palmitoylethanolamide; polydatin
Categories
Ask authors/readers for more resources
Aim. To demonstrate clinical effectiveness of micronized palmitoylethanolamide-transpolydatin combination in reducing endometriotic chronic pelvic pain. Other endometriotic-pains were also assessed. Methods. Systematic reviews of PubMed, SCIELO, Scopus, and AJOL. Randomized trials and observational studies reporting a visual analogue scale for pain or similar in endometriotic patients were reviewed. A mean improvement of visual analogue scale ( or visual analogue scale-like) scores at enrollment and at a three-month follow-up was assessed and interpreted clinically. Results. Four studies of poor quality were available. In a heterogeneous sample of endometriotic patients with pain, the administration of micronized palmitoylethanolamide/trans-polydatin (400 mg/40 mg) twice a day for three months provided a clinically relevant improvement of chronic pelvic pain and dysmenorrhea while improving deep dyspareunia to a limited degree. No clinically relevant improvement was found for dyschezia. Conclusion. More studies are warranted for assessing the drugs-related efficacy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available