Journal
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
Volume 6, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s40164-017-0083-4
Keywords
4Macrophage; Phenotype; Polarization; Homeostasis; Cancer
Categories
Funding
- National Natural Science Foundation of China [31430089]
- National Program on the Key Basic Research Project [2015CB755903]
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Macrophages are an essential component of innate immunity and play a vital role in inflammation and host defense. Based on immunological responses, the macrophages are classified into activated macrophage (M1 macrophages) participating in the responses of type I helper T (Th1) cells to pathogens and alternatively activated macrophages (M2 macrophages) in response to interleukin (IL)-4 and IL-13. In this review, we discuss the origin, classification and function of macrophages. We also discuss the mechanisms underlying polarization of different macrophage subtypes, including transcriptional, epigenetic and post-transcriptional regulation.
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