Journal
ACS CATALYSIS
Volume 7, Issue 4, Pages 2425-2429Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b00300
Keywords
asymmetric catalysis; 1,1,2-triarylethanes; arylboration; cross-coupling; modular synthesis
Categories
Funding
- NSFC [21472184, 21272226, 21572218, 21402186]
- Western-Light Foundation of CAS
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An enantioselective Cu/Pd-catalyzed borylative coupling of styrenes with aryl/alkenyl iodides was realized using a chiral sulfoxide-phosphine (SOP) ligand. Enantioenriched 1,1-diarylethyl and beta-arylhomoallylic boronates are readily prepared. A streamlined procedure merging arylboration and subsequent Pd-catalyzed Suzuki-Miyaura cross-coupling enables the modular assembly of enantioenriched 1,1,2-triarylethanes, including two medicinally important chiral small-molecule targets.
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