Journal
ACS CATALYSIS
Volume 7, Issue 7, Pages 4441-4445Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b01123
Keywords
Cu-catalyzed; tandem borylation
Categories
Funding
- National Institutes of Health [R01GM116987, 3R01GM116987-01S1]
- University of North Carolina at Chapel Hill
Ask authors/readers for more resources
Catalytic enantioselective synthesis of 1-hydroxy-2,3-bisboronate esters through multicomponent borylation/1,2-addition is reported. Catalyst and substrates are readily available, form both a C-B and C-C bond, and generate up to three contiguous stereocenters. The reaction is tolerant of aryl, vinyl, and alkyl aldehydes and ketones in up to 95% yield, >20:1 dr, and 99:1 er. Intramolecular additions to aldehydes and ketones result in stereodivergent processes. The hydroxy bis(boronate) ester products are amenable to site-selective chemical elaboration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available