Journal
CELL BIOLOGY INTERNATIONAL
Volume 41, Issue 8, Pages 890-897Publisher
WILEY
DOI: 10.1002/cbin.10806
Keywords
-3 polyunsaturated fatty acids; breast cancer; cell apoptosis vitamin D-3; cell proliferation
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Funding
- National Natural Science Foundation of China [31471321]
- Young-Thousand-talents Plan
- Jiangsu Province Recruitment Plan for High-level, Innovative and Entrepreneurial Talents
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Breast cancer is a leading type of cancer in women and generally classified into three subtypes of ER+/PR+, HER2(+) and triple negative. Both omega-3 polyunsaturated fatty acids and vitamin D-3 play positive role in the reduction of breast cancer incidence. However, whether combination of omega-3 polyunsaturated fatty acids and vitamin D-3 has stronger protective effect on breast carcinogenesis still remains unknown. In this study, we show that the combination of -3 free fatty acids (-3 FFAs) and 1, 25-dihydroxy-vitamin D-3 (VD3) dramatically enhances cell apoptosis among three subtypes of breast cancer cell lines. Bcl-2 and total PARP protein levels are decreased in combined treatment MCF-7 and SK-BR-3 cells. Caspase signals play a vital role in cell apoptosis induced by combination. Moreover, Raf-MAPK signaling pathway is involved in the apoptosis induction by combination of -3 FFAs+VD3. These results demonstrate that the induction of cell apoptosis by combined treatment is dependent on different signaling pathways in three subtypes of breast cancer cell lines.
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