Journal
ACS CATALYSIS
Volume 7, Issue 10, Pages 6798-6801Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b02567
Keywords
gold catalysis; hydrochlorination; chloride-tolerant; alkyne; HCI/DMPU
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Funding
- National Institutes of Health [1R01GM121660-01]
- National Science Foundation of China [NSFC-21472018]
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We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air.
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